KrosFlo® FS TFF Systems

Modular, plug-and-play hardware with diaphragm pump

The KrosFlo® FS Systems achieve an unparalleled combination of configurability and automation and compliance for flat sheet TFF processes. All components, either directly or indirectly, connect to the main KrosFlo® FS diaphragm pump, which then communicates with the KF Comm 2 software for control and monitoring.

• Configure a minimal number of components for simple applications such as concentration (C) or diafiltration (D)
• Plug-and-play additional components for fractionation (F) and multi-step processes (i.e. CDC/D/C)

Automatic Back Pressure Control Valve

A Repligen-exclusive technology, the Automatic Back Pressure Control Valve adds transmembrane pressure (TMP) control to every TFF process, reducing operator hands-on-time and improving process reproducibility.

• Automatically adjust tubing pinch distance according to user-defined set-points
• Maintain uniform TMP throughout process run, decreasing membrane fouling
• Control permeate pressure and flow during microfiltration applications
• Use with compatible tubing sizes 13, 14, 16, 25, HP15, 17, HP24, 18, HP35, 36, and HP36
• Activate automatically using inlet, retentate, permeate or transmembrane pressures

Scale effortlessly from Lab to Pilot Manufacturing

Transition seamlessly from small scale to larger scale processes. The KrosFlo^® FS-15 handles volumes as small as 140 mL to 15 L. The KrosFlo^® FS-500 is capable of larger volumes from 1.25 L to 500 L. These two KrosFlo^® FS TFF Systems share common hardware architecture, software and pump technology.

• Scale-up and scale-down with a single platform
• Configurable across applications (C, D and CFC/D/C)
• Operate 21 CFR Part 11 compliant software built on secure Microsoft^® SQL Server

KrosFlo^® FS TFF Systems

The fully integrated KrosFlo^® FS TFF System consists of hardware, software and flow path components. Key hardware components include: a diaphragm pump, auxiliary pumps and an automatic back pressure valve.

The KF Comm 2 software features a multi-language interface for complete monitoring and control and an optional 21 CFR Part 11 environment. Add tubing and sanitize/sterilize your own flow path around a Spectrum^® hollow fiber filter or build a closed and gamma-irradiated ProConnex^® Flow Path from over 250 components.