Yokogawa Advanced Control Bioreactor System

YOKOGAWA BR1000 ADVANCED CONTROL BIOREACTOR SYSTEM

Yokogawa experts have assembled and integrated the most effective PAT-driven bioreactor hardware and software tools for CHO cell biologic expression and advanced control.

Bioprocess Needs

• Real-time monitoring with in-line sensing
• Measure and control of glucose concentration with high precision
• High cell culture reproducibility from batch to batch

YOKOGAWA's Solutions

Achieving automation of mammalian cell culture through real-time monitoring and high-precision advanced control

• In-line soft sensors: Real-time monitoring of cellular activity
• Advanced control: Automated process control of critical cell culture variables
• Powerful custom support: Calibration tools to improve and customize the accuracy of in-line sensors

Key Highlights

• Refinement of the cell culture calibration model
• Precision control of glucose and alignment with off-line analytical Data
• Basic control of physical parameters such as pH, temperature, DO
• In-line sensor for measurement of glucose and lactate
• In-line sensor for viable cell density
• Soft Sensor estimation of specific rates

Performance Benefits

Optimal glucose control for your cell line leads to enhanced stability and efficiency of bioreactor performance including better batch-to-batch reproducibility, higher productivity and improved product quality

• Integrated Instrumentation: provides basic control of pH, temperature, and dissolved oxygen, in-line sensors to monitor cell growth and metabolism, feed control, and data-logging in one complete system
• Powerful support: Provides calibration modeling tools to improve the accuracy of in-line sensors specifically for your expression system
• Technical support: Engineering and application support for cell culture provided locally and remotely

Cell Culture Calibration Model

Cell State Measuring Technology