Rethink Expression. One Toolbox Several Impactful Choices

Diversity of biotherapeutics requires a toolbox approach for expression options. XS Technologies^® (including the XS^® Pichia   and E.coli   Expression Systems) is an extensive expression toolbox that allows you to go to your lab with Lonza’s support where you need the most. It is the same highly productive and scalable platform we use for our in-house services, so you can be confident in its ability to enable high-yielding processes for a wide variety of molecules.

If you are new to microbial platforms for protein expression, be assured that our technical experts can help you optimize your strategy, balancing risks while ensuring your processes meet regulatory requirements. A simple host-screening and support from our technical team can help you choose which system would work best for your molecule.

We routinely see productivities of up to 20 g/L for less complex therapeutic proteins, above 5 g/L for novel scaffolds and up to 600 mg/L for pDNA using microbial expression systems

XS^® Pichia Expression System

Lonza’s XS^® Pichia Expression System is the best in class for complex, non-glycosylated protein production. Its features include:

• Bacteria-like short fermentation time
• Simple and fast strain development
• Methanol-free fermentation
• No viral clearance required
• Highly pure product
• Protein secretion
• No endotoxin

XS^® E.coli Expression System

E. coli is one of the most trusted and established organisms for the expression of simple to moderately complex biologics. Its features include:

• Reduced antibiotic requirements
• Simpler downstream processes
• Robust upstream processes
• Tunable expression
• Easy scalability
• High titers